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Citra-Lock 4% :

1. Superior antimicrobial activity of trisodium citrate over heparin for catheter locking, Marcel C. Weijmer, Yvette J. Debets-Ossenkopp, Francien J. van de Vondervoort and Piet M. ter Wee, Department of Nephrology and Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, Amsterdam, The Netherlands, Nephrol Dial Transplant (2002) 17: 2189–2195
2. Filling hemodialysis catheters in the interdialytic period: heparin versus citrate versus polygeline: a prospective randomized study. Buturovic J, Ponikvar R, Kandus A, Boh M, Klinkmann J, Ivanovich P Department of Nephrology, University Medical Center, Ljubljana, Slovenia. Artif Organs 1998 Nov;22(11):945-7
3. Risk of heparin lock-related bleeding when using indwelling venous catheters in haemodialysis, Hüseyin Karaaslan, Pierre Peyronnet, Daniel Benevent, Christian Lagarde, Michel Rince, Claude Leroux-Robert, Service de Néphrologie CHU Dupuytren, Limoges, France, Nephrol Dial Transpant, (2001) 16: 2072-2074
4. A comparative prospective study on the use of low concentrate citrate lock versus heparin lock in permanent dialysis catheters, Hendrickx L, Kuypers D, Evenepoel P, Maes B, Messiaen T, Vanrenterghem Y, Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium. Int J Artif Organs 2001 Apr;24(4):208-11
5. Concentrated Sodium Citrate (23%) for Catheter Lock, Stephen R. Ash, Rita A. Mankus, James M. Sutton, Ruth E. Criswell, Carol C. Crull, Katherine A. Velasquez, Brian D. Smeltzer, Todd S. Ing, Greater Lafayette Healthcare Services, Inc. (previously St. Elizabeth Medical Center and Lafayette Home Hospital); Arnett Clinic, Lafayette; HemoCleanse, Inc. and Ash Medical Systems, Inc.,West Lafayette, Indiana; University of Illinois, Chicago, Illinois, U.S.A. Hemodial Int 2000;4: 22-31
6. Sodium citrate 4% versus heparin as a lock solution in hemodialysis patients with central venous catheters, Calantha K. Yon and Chai L. Low, Am J Health-Syst Pharm. 2013; 70:131- 6
7. Diagnosis, prevention and treatment of haemodialysis catheter-related bloodstream infections (CRBSI): a position statement of European Renal Best Practice (ERBP), Raymond Vanholder1, Bernard Canaud2, Richard Fluck3, Michel Jadoul4, Laura Labriola4, A. Marti- Monros5, J. Tordoir6 and W. Van Biesen1 1Nephrology Section, Department of Internal Medicine, University Hospital, Gent, Belgium, 2Nephrology, Dialysis and Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France, 3Department of Renal Medicine, Royal Derby Hospital, Derby, UK, 4Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium, 5Nephrology Department, Consorcio Hospital General Universitario, Valencia, Spain and 6Vascular Surgery, Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands NDT Plus (2010) 3: 234–246 doi: 10.1093/ndtplus/sfq041
8. Morphometric and biological characterization of biofilm in tunneled hemodialysis catheters, Jones SM, Ravani P, Hemmelgarn BR, Muruve D, Macrae JM. Division of Nephrology, University of Calgary, Calgary, Alberta, Canada. Am J Kidney Dis. 2011 Mar;57(3):449-55. Epub 2011 Jan 22.
9. Sodium citrate 4% locking solution for central venous dialysis catheters—an effective, more cost-efficient alternative to heparin, Linda Grudzinski1, Patricia Quinan1, Sophie Kwok1 and Andreas Pierratos1,2 1Department of Nephrology, Humber River Regional Hospital and 2Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Nephrol Dial Transplant (2007) 22: 471–476
10. Trisodium citrate 4%—an alternative to heparin capping of haemodialysis catheters, Charmaine E. Lok, Debra Appleton, Cynthia Bhola, Brian Khoo and Robert M. A. Richardson, Department of Medicine, Division of Nephrology, The Toronto General Hospital, Nephrol. Dial. Transplant. (2007) 22 (2): 477-483.
11. Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces, Robert M. Q. Shanks1, Jennifer L. Sargent1, Raquel M. Martinez1, Martha L. Graber2 and George A. O’Toole1 1Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755 and 2Department of Medicine, Section of Hypertension and Nephrology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA Nephrol Dial Transplant (2006) 1 of 9 doi:10.1093/ndt/gfl170

Citra-Lock 30% & Citra-Lock 46,7% :

1. Ash SR (2000) Concentrated Sodium Citrate (23%) for Catheter Lock. Haemodialysis International 4:22-31
2. Weijmer JC (2005) Randomized, Clinical Trial Comparison of Trisodium Citrate 30% and Heparin as Catheter-Locking Solution in Haemodialysis Patients. J Am Soc Nephrol. Sep;16(9):2769-77
3. Weijmer JC (2002) Superior Antimicrobial Activity of Trisodium Citrate over Heparin for Catheter Locking. Nephrol Dial Transplant 17: 2189-2195
4. Shanks RM (2006) Catheter Lock Solutions Influence Staphylococcal Biofilm Formation on Abiotic Surfaces. Nephrol Dial Transplant 21, 2247-2255
5. Nolan JP (2007) Reducing Catheter Related Bacteraemia in Haemodialysis. Vascular Access Soc. 5th Int. Congress of Vascular Access Soc, Nice
6. VU Amsterdam(2005), Agar diffusion susceptibility test for heparine, Cita-Lock30% en Citra-Lock 46,7%, Microbiological lab VU Amsterdam
7. Buturovic J (1998) Filling hemodialysis catheters in the interdialytic period: heparin versus citrate versus polygeline: a prospective randomized study, 1998 Nov;22(11):945-7
8. Hendrikx L (2001) A comparative prospective study on the use of low concentrate citrate lock versus heparine lock in permanent dialysis catheters. Int J Artif Organs 2001 Apr; 24(4):208-11
9. Donlan RM (2001) Biofilms and Device-Associated Infections. Emerging Infectious Diseases, Vol. 7, No. 2, March-April 2001
10. Karaaslan H (2001) Risk of heparin lock-related bleeding when using indwelling venous catheter in haemodialysis. Neprol Dial Transplant (2001) 16: 2072-2074
11. Nielsen J (1998) Staphylococcus aureus bacteraemia among patients undergoing dialysis-focus on dialysis catheter-related cases. Nephrol Dial Transplant (1998) 13: 139-145
12. Jean G (2002) Risk factor analysis for long-term tunneled dialysis catheterrelated bacteremias. Nephron 2002 Jul;91(3):399-405
13. Jeffrey S. Berns JS (2002) Preventing Bacterial Infections and Antimicrobial Resistance in Dialysis Patients. American Journal of Kidney Diseases, Vol 40, No 5 (November), 2002:pp 886-898
14. Peleman RA (2000) Changing patterns of antibiotic resistance- update on antibiotic management of the infected vascular access. Neprol Dial Transplant (2000) 15: 1281-1284
15. Betjes MGH (2004) Prevention of dialysis catheter-related sepsis with a citrate- taurolidine-containing lock solution. Nephrol Dial Transplant (2004) 19: 1546-1551
16. Doorenbos CJ (2005) Estimation of trisodium citrate (Citra-LockTM) remaining in central venous catheters after the interdialytic interval. Nephrol Dial Transplant (2005) 1 of 3, doi:10.1093/ndt/gfi331
17. Agharazii M (2005) Estimation of heparin leak into the systemic circulation after central venous catheter heparin lock. Nephrol Dial Transplant (2005) 20: 1238-1240, doi:10.1093/ndt/gfh841
18. Srivastava R (2004) The case of the floating gel. J Clin Pathol 2004;57:1333-1334. doi: 10.1136/jcp.2004.020495
19. Lagaac R (2011) Catheter Care Management in Haemodialysis, European Nephrology, 2011;5(2):138-42
20.Sanchez R (2012) Our experience using Citra-Lock 30% to maintain the patency of permanent tunneled vascular catheter, Britis Renal Society, poster presentation, June 12th 2012

General info and Dialysis studies

1. Anticoagulation in Haemodialysis
2. Standard of Care for Maintenance Haemodialysis in India
3. How to deal with Dialysis Catheters in the ICU setting
4. Catheter Related Blood Stream Infections in ICU India
5. Epidemiology of healthcare acquired infection - An Indian perspective

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

Dialec Medical Services Pvt. Ltd.

Block GA, 4th Floor, NPR Complex, Plot No 311 Survey No 197, Hoody Village KR Puram Hobli Mahadevapura Post, Bangalore-560048

Send an e-mail

[email protected]



Call us

+91-9538730345

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